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In this study, the effect of a nature flavonoid, curcumin, on IOL-induced rats liver oxidative damage was investigated. Sixty male albino rats were randomly divided into three equal groups. Group I: Control group, Group II: Iron-overload group, received six doses (three doses per week) of ferric hydroxide poly maltose (100 mg kg-1 b. wt. ) by intraperitoneal injections (IP) and Group III: Iron.